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Ubayd Ali

Authored by

Ubayd Ali

Superintendent Pharmacist

Registration Number: 2219322

NHS Pharmacist and founding member of HEBA, with years of experience in healthcare across innovative organisations.
Sufyan Tahir

Reviewed by

Sufyan Tahir

Clinical Governance Lead

Registration Number: 2221275

Review Date 28 April 2026
Next Review 28 April 2028
Published on 28 April 2026
Last Update 28 April 2026

What is Malarone?

Malarone is an antimalarial. It contains two active ingredients, atovaquone and proguanil hydrochloride. It has two uses: to prevent malaria and to treat malaria. Malaria is spread by the bite of an infected mosquito, which passes the malaria parasite (Plasmodium falciparum) into the bloodstream. Malarone prevents malaria by killing this parasite. For people who are already infected with malaria, Malarone also kills these parasites.

How do I use Malarone?

Take Malarone with food or a milky drink, where possible.

It is best to take Malarone at the same time each day.

 

To prevent malaria:

The recommended usual dose for adults is 1 tablet once a day, taken as below. 

Not recommended for preventing malaria in children, or in adults who weigh less than 40 kgs. Malarone paediatric tablets are recommended for preventing malaria in adults and children who weigh less than 40 kgs.

 

To prevent malaria in adults:

  • Continue taking it every day during your stay
  • Start taking Malarone 1 to 2 days before travelling to an area which has malaria
  • Continue taking it for another 7 days after your return to a malaria-free area

 

To treat malaria:

The recommended dose for adults is 4 tablets once a day for 3 days

What are the side effects of Malarone?

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Common side effects:

  • Stomach pain
  • Headache
  • Nausea and vomiting
  • Diarrhoea

Look out for the following severe reactions such as, severe skin reactions and severe allergic reactions. Contact a doctor immediately if you get any of these symptoms. Stop taking Malarone.

For a complete list of side effects, please read the patient information leaflet.

What precautions should I take with Malarone?

This medicine may not be suitable for everyone to take. Please ensure you provide us with all the information requested when completing your assessment form. This is to ensure a safe supply is made.

Do not take this medicine if:

  • Are allergic to any of the listed ingredients
  • You are pregnant or breastfeeding
  • You have severe kidney disease

Malarone - Patient information leaflet

Malarone - Summary of product characteristics 

Verified customer reviews

Frequently asked questions

  • What is Malarone?

    Malarone is an antimalarial. It contains two active ingredients, atovaquone and proguanil hydrochloride. It has two uses: to prevent malaria and to treat malaria.

  • How does Malarone work?

    Malaria is spread by the bite of an infected mosquito, which passes the malaria parasite (Plasmodium falciparum) into the bloodstream. Malarone prevents malaria by killing this parasite.

  • Is there a generic version of Malarone?

    Yes, the generic form of Malarone also contains atovaquone and proguanil and is medically equivalent to the branded version.

  • Is there a difference between branded and generic Malarone?

    Both contain the same active ingredients—atovaquone and proguanil—and are equally effective. Differences lie in branding, packaging, and cost.

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