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How it Works

  • Adapalene belongs to a group of products known as retinoids and acts specifically on the skin processes that cause acne. It normalises skin cell turnover and reduces inflammation.  
  • Benzoyl peroxide kills acne‑causing bacteria and exfoliates dead skin. It works as an antimicrobial agent and by softening and peeling the outer layer of the skin. 

Directions

  • Apply once daily, usually at bedtime. 
  • Use on clean, dry skin and avoid eyes, mouth, nostrils. 
  • Wash hands after application and avoid sunlight/sunlamps. 
  • Avoid bleaching materials such as fabrics and hair.  

Side‑Effects

Common:

  • burning, dryness, redness, peeling, irritation

These typically improve with continued use.

Warnings

  • Not to be used in pregnancy. 
  • Avoid other irritant acne products and avoid application to broken/sunburned skin. 

Patient Information Leaflet (EMC)

https://www.medicines.org.uk/emc/product/451/pil

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Frequently asked questions

  • How long until Epiduo shows results?

    NICE recommends an 8–12 week review, as combination retinoid + benzoyl peroxide therapies often show improvement within that timeframe.

  • Why is Epiduo considered a first‑line option?

    NICE lists fixed adapalene + benzoyl peroxide as a first‑line option for mild–moderate acne because it tackles multiple acne pathways without using antibiotics.

  • Does Epiduo help prevent scarring?

    By treating both inflammatory and comedonal lesions, it reduces the number of breakout cycles, which can lower scarring risk.

  • What should I do if irritation happens?

    Irritation is common during the first few weeks. NICE advises adjusting frequency or adding non‑comedogenic moisturisers if needed.

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Why go with HEBA?

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UK-based clinical team

Our specialist clinical team ensure your safety and health. Every treatment is carefully reviewed with treatment provided based on your overall health.
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Clinically proven treatments, safely prescribed

We are a GPhC registered pharmacy, dispensing medication from MHRA approved facilities. You can rest assured that your medication will always be 100% genuine and authentic.
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Long term support

We are committed to providing assistance and guidance for your well-being and health, with a focus on long-term health outcomes and holistic support to ensure that you are getting the most from your treatment.
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Treatment plans personalised to you

We customise your treatment plan to fit your needs and health profile.
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