Mounjaro at Heba

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Mounjaro

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The Mounjaro dose schedule

Here's what the standard Mounjaro dosing schedule looks like if you're tolerating the medication well and your dose increases every 4 weeks. Please note that every patient's journey is different and you may not necessarily need to be increased to the maximum dose. Maintenance plans are also reviewed on an individual basis:

Week	Dose	Price
1-4	2.5mg	£169
5-8	5mg	£189
9-12	7.5mg	£259
13-16	10mg	£299
17-20	12.5mg	£309
21+	15mg	£319

Authored by

Ubayd Ali

Superintendent Pharmacist

Registration Number: 2219322

NHS Pharmacist and founding member of HEBA, with years of experience in healthcare across innovative organisations.

Reviewed by

Sufyan Tahir

Clinical Governance Lead

Registration Number: 2221275

Review Date 16 March 2026

Next Review 16 March 2028

Published on 16 March 2026

Last Update 16 March 2028

What is Mounjaro?

Mounjaro is a prescription-only medication manufactured by Eli Lilly for weight management and type 2 diabetes. It is a once-weekly subcutaneous (under the skin) injection that contains the active ingredient tirzepatide.

Tirzepatide mimics two important gut hormones: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). These hormones work together to reduce appetite, help you feel fuller for longer, slow stomach emptying, and improve blood sugar control. This dual mechanism makes Mounjaro different from other weight loss injections like Wegovy, which only target the single hormone GLP-1.

Mounjaro has been clinically proven to deliver significant weight loss results, making it one of the most effective prescription weight loss treatments available.

How does Mounjaro work in the body for weight loss?

Mounjaro works by mimicking two naturally occurring gut hormones that regulate appetite, blood sugar, and metabolism. Understanding how these hormones work helps explain why Mounjaro is so effective for weight loss.

What is GLP-1?

GLP-1 (glucagon-like peptide-1) is a hormone your gut releases after eating. It plays a key role in controlling appetite and blood sugar.

GLP-1 slows how quickly the stomach empties, helping meals feel more satisfying and keeping you fuller for longer. It also sends signals to the brain that reduce appetite and curb cravings.

After eating, GLP-1 boosts insulin release as blood sugar rises and suppresses glucagon, a hormone that would otherwise raise your blood sugar between meals. This helps keep energy levels steady throughout the day.

By activating the GLP-1 receptor, Mounjaro helps you feel satisfied with smaller portions and makes it easier to stick to a reduced-calorie diet.

GLP-1 is the same receptor targeted by Wegovy (semaglutide), but Mounjaro goes further by also activating a second hormone pathway.

What is GIP?

GIP (glucose-dependent insulinotropic polypeptide) is another gut hormone that works alongside GLP-1 to regulate metabolism and appetite.

GIP helps the body use insulin more effectively after meals, allowing blood sugar levels to settle more smoothly. In the brain, GIP signals can dampen appetite, making it easier to feel satisfied with smaller portions.

Mounjaro is currently the only licensed weight-loss medicine that activates the GIP receptor (as well as GLP-1).

How should Mounjaro be taken?

Mounjaro uses a gradual dose increase schedule, starting at the lowest dose and building up over time. This approach, called titration, helps your body adjust to the medication and minimises side effects while maximising weight loss results.

The Mounjaro dose schedule

Here's what the standard Mounjaro dosing schedule looks like if you're tolerating the medication well and your dose increases every 4 weeks:

Mounjaro dosage	Week
2.5 mg	1–4
5 mg	4–8
7.5 mg	8–12
10 mg	12–16
12.5 mg	16–20
15 mg	20–24

Not everyone will reach the highest dose, and your journey may look different. The aim is to find your stable dose: the level that gives you strong appetite control, effective weight loss, and minimal side effects. For many people, this may be 7.5 mg, 10 mg, or 12.5 mg rather than the full 15 mg.

Why your pace might differ

Your clinician may recommend staying on a dose for longer than 4 weeks or even reducing the dose if you experience side effects. You may also choose to remain on your current dose if you're achieving great results and don’t feel the need to increase.

At HEBA, our clinical team works closely with you to find the right pace and dose for your individual needs.

Can you start at a higher dose?

Most people begin Mounjaro at the lowest dose of 2.5 mg. This is important because:

It reduces side effects: A lower starting dose helps your body adjust and lowers the risk of nausea, vomiting, and other side effects.
It improves long‑term success: Gradual increases lead to fewer treatment breaks and more consistent progress.
It allows steady-state levels to form: Mounjaro takes about 4 weeks to stabilise in your system, making a low starting dose the safest approach.

Exception — Switching from Another Medication

If you’re moving to Mounjaro from another GLP‑1 medication like Wegovy, you may be eligible to start at a higher dose to support a smooth transition. This is considered off‑label prescribing. At HEBA, your clinician will review your treatment history and the latest evidence to recommend the safest, most effective starting dose for you.

Can you stay on 2.5mg?

Yes, you can remain on 2.5 mg if you’re experiencing good appetite suppression and strong weight‑loss results. However, 2.5 mg is mainly intended as a starting dose to help your body adjust. Over time, your body will adapt, and the effects may lessen, meaning most people eventually increase their dose to continue seeing progress.

What results can you expect with Mounjaro?

You can expect to see on average, a 22.5% decrease in weight over 72 weeks as evidenced by clinical trial data.

Weight loss with Mounjaro varies from person to person. Your individual outcome depends on several factors:

Lifestyle changes: Mounjaro works best alongside a balanced diet and regular physical activity
Consistency: Taking your prescribed dose every week without missing injections
Side effect management: Working with your clinical team to manage any side effects so you can stay on treatment
Dose and duration: Higher doses and longer treatment duration generally lead to greater weight loss
Individual factors: Your medical history, other medications you're taking, and how your body responds to treatment

Our team at HEBA focuses greatly on wraparound care, and you will have a structured plan to aid your weight loss journey.

What other benefits does Mounjaro have?

While Mounjaro is best known for weight loss, it offers several other health benefits.

Blood sugar control

Mounjaro is licensed to treat type 2 diabetes and has been shown to significantly improve blood sugar control.

High blood sugar can damage your nerves, kidneys, and eyes over time. It can also contribute to weight gain, as excess sugar is stored as fat. Mounjaro helps control blood sugar levels by:

Stimulating the pancreas to produce more insulin when blood sugar rises
Suppressing glucagon (a hormone that raises blood sugar), which reduces glucose production in the liver
Slowing stomach emptying, which helps prevent blood sugar spikes after meals
Improving insulin sensitivity (particularly as weight decreases)

What about prediabetes?

Mounjaro is not licensed specifically for prediabetes, but if you have prediabetes and meet the eligibility criteria for weight loss, you can be prescribed it.

Losing weight is one of the most effective ways to reverse prediabetes and prevent progression to type 2 diabetes. Mounjaro also helps reduce blood sugar levels directly, which provides additional metabolic benefits.

Clinical evidence supports this: in a 176-week study, patients taking tirzepatide had a 93% lower risk of developing type 2 diabetes compared to placebo. More than 90% of those on tirzepatide achieved normal HbA1c levels (a measure of average blood sugar over 3 months) by the end of the study.

Heart health and cardiovascular benefits

Reaching a healthier weight can significantly improve your heart health by lowering blood pressure and cholesterol levels.

Studies have shown that Mounjaro can:

Lower blood pressure
Reduce cholesterol levels
Improve cardiovascular risk markers

Please note - Mounjaro is not approved for cardiovascular risk reduction at this present time, these are benefits from weight loss.

Cardiovascular risk reduction:

Research shows promising cardiovascular benefits with Mounjaro. A 2024 study of over 7,000 participants found a 33% reduction in major cardiovascular events such as heart attack, stroke, and heart failure. This compares favourably to Wegovy (semaglutide), which showed a 20% reduction in the SELECT trial and is licensed for cardiovascular risk reduction.

Mounjaro is not yet licensed specifically for cardiovascular protection, but ongoing trials are evaluating its long-term heart health benefits.

What are the potential side effects of Mounjaro?

Like all medications, Mounjaro can cause side effects, though not everyone experiences them. Most side effects are mild and temporary, typically improving within a few days to weeks as your body adjusts to the medication.

What are the most common Mounjaro side effects?

The most common side effects of Mounjaro affect the digestive system and usually occur when starting treatment or increasing your dose.

Very common side effects (may affect more than 1 in 10 people):

Nausea
Diarrhoea
Vomiting
Constipation
Stomach pain or discomfort

Common side effects (may affect up to 1 in 10 people):

Indigestion
Feeling tired or low energy
Injection site reactions (redness, itching, or pain)
Burping
Gas or bloating
Acid reflux or heartburn
Dizziness
Hair loss (usually temporary)

Side effects support at HEBA

It's normal to experience side effects when you start taking Mounjaro or after increasing your dose. If you need support managing side effects, call our support line on 0141 337 3000 (available Monday to Saturday, 9 AM to 5 PM).

The HEBA Clinical Team can:

Provide advice on managing symptoms
Prescribe treatment to help with side effects
Adjust your dose to find the right balance

How long will I need to stay on Mounjaro?

Most people take Mounjaro for at least a year, and many continue long‑term to maintain their results. Clinical studies show that weight loss continues throughout the first 72 weeks (around 18 months) of treatment. At the highest 15 mg dose, participants lost an average of 22.5% of their starting weight after 72 weeks—these outcomes are typically seen in people who remain on the medication long‑term.

How long you may need to take Mounjaro

Your treatment duration depends on factors such as:

Your starting weight and how much you want to lose
Your wider health goals, including blood sugar control if you have type 2 diabetes
Whether you plan to continue on a maintenance dose or stop once you reach your goal weight

Why long‑term treatment matters

Weight‑loss medication works best when paired with lasting lifestyle changes. Staying on Mounjaro long‑term gives you the time and support to build sustainable habits around food, movement, and routine. These habits help maintain your results whether you eventually stop the medication or transition to a lower maintenance dose.

At HEBA, we support you throughout your journey to help you develop the behaviours that keep weight off for good.

What is the maintenance dose?

Once you reach your goal weight, a maintenance dose is used to help you maintain your results without continuing to lose weight or regaining it.

Your maintenance dose is personalised at HEBA Online Pharmacy. For some, this may be 5 mg or 7.5 mg; for others, it may be 10 mg or 12.5 mg. The right maintenance dose is the one that:

Keeps your appetite well‑controlled
Helps you maintain your weight loss
Minimises side effects
Supports your long‑term health goals

Your clinical team will help determine when you've reached a stable weight and are ready to shift from active weight loss to maintenance. This usually happens once your weight has remained steady for several weeks.

Who should not take Mounjaro?

Mounjaro is not suitable if you:

Are under the age of 18
Are trying to conceive, pregnant, or breastfeeding
Are allergic to any of the ingredients in Mounjaro
Have type 1 diabetes
Have a personal or family history of thyroid cancer
Have Multiple Endocrine Neoplasia Type 2
Have severe digestive conditions such as Ulcerative Colitis, Crohn's disease, or gastroparesis
Have a history of pancreatitis
Have severe liver or kidney impairment
Have gallbladder problems (unless your gallbladder has been removed)
Have diabetic retinopathy
Medications that may interact with Mounjaro
Other weight loss medications: You should not take Mounjaro alongside other weight loss injections (like Wegovy or Saxenda) or orlistat. Using multiple weight loss medications together is not safe or recommended.

Diabetes medications: Mounjaro can interact with insulin and sulfonylureas (like gliclazide), increasing the risk of dangerously low blood sugar. If you're taking these medications, Mounjaro may not be suitable.

Oral contraceptives: Mounjaro can make oral contraceptive pills less effective. If you're taking the pill, you should use additional contraception (like condoms or an IUD) for 4 weeks after starting Mounjaro and for 4 weeks after each dose increase.

Other medications: Because Mounjaro slows stomach emptying, it may affect how your body absorbs other oral medications. Tell your clinician about all medications you're taking, including over-the-counter drugs and supplements.

Further Information

Patient Information Leaflet

Summary of Product Characteristics

Month 0-3

Kickstart your journey

The first month focuses on adjustment, not quick weight loss. Hunger and cravings decrease as the body adapts. Consistency is key.

Start feeling less hungry
Less food noise
Noticeable weight loss progress and more energy

It can take up to 8 weeks to start feeling the effects of your medication, but it will start working in your body after the first week.

Months 3 - 6

Positive changes

From months three to six, weight loss is clear. Smaller portions help with calorie deficit.

A noticeable reduction in bodyweight
Be more active and making healthier food choices
With HEBA Online Pharmacy, gain education on relationship with food

As your dosage increases you should see changes in your weight and your lifestyle.

Months 6+

Maintenance phase

After six months, many reach a new weight. Focus shifts to maintaining results and preventing regain.

Continued weight loss
Improvements in measurable health metrics e.g. reduced blood pressure, improved cholesterol or blood glucose control
Formulate a personal comprehensive plan for long-term weight control

This is a period where you’ll see sustained weight loss and be in a consistent weight management rhythm.

Lose up to 22.5% of your body weight in less than 72 weeks

*This calculator is only an example for illustrative purposes and the results are not guaranteed. Every weight loss experience is unique. This example is based on research showing weight loss of up to 22.5% over a 72-week period

Lisa F.

After losing 17kg with medication and committing to the gym, I’ve finally learned to love myself again. For the first time in years, I feel proud, confident, and truly in control of my life.

Nusrat A.

I've lost 13kg, but honestly the bigger win is how I feel.

I started HEBA's weight loss program not really knowing what to expect. A year on, I'm 13kg lighter, I've cut out sugar, and I'm at the gym four times a week — something I never thought I'd say. The team checked in regularly and kept me on track, but the habits are mine now. I've got my energy back, and for the first time in years, it feels sustainable.

Frequently asked questions

What is Mounjaro?

Mounjaro is a prescription-only weight loss injection containing tirzepatide. It is licensed in the UK for chronic weight management in adults with obesity (BMI ≥30) or overweight (BMI ≥27) with at least one weight-related health condition such as type 2 diabetes, high blood pressure, or high cholesterol. It is used alongside a reduced-calorie diet and increased physical activity.
How does Mounjaro work?

Mounjaro contains tirzepatide, which uniquely activates both GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) receptors. This dual-hormone action reduces appetite, slows gastric emptying, and improves blood sugar regulation — helping you feel fuller for longer and eat less overall.
How much weight can I lose with Mounjaro?

In clinical trials, participants using Mounjaro at the highest dose (15mg) lost an average of up to 22.5% of their body weight over 72 weeks. Results vary depending on individual factors including starting weight, diet, and activity levels. Mounjaro is currently the most effective licensed weight loss injection available in the UK.
How is Mounjaro administered?

Mounjaro is given as a once-weekly subcutaneous (under the skin) injection using the pre-filled KwikPen. It can be injected into the abdomen, thigh, or upper arm. The day of the week can be chosen by you and changed if needed, as long as injections remain at least 3 days apart.
What doses does Mounjaro come in?

Mounjaro is available in the following doses: 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, and 15mg. Treatment always starts at 2.5mg once weekly for the first 4 weeks, with gradual dose escalation every 4 weeks to minimise side effects and allow your body to adjust.
Do I need a prescription for Mounjaro?

Yes. Mounjaro is a Prescription Only Medicine (POM) in the UK. At HEBA Online Pharmacy, you will be required to complete a clinical assessment before a prescription can be issued. This ensures Mounjaro is safe and appropriate for you.
Who is eligible for Mounjaro?

Mounjaro is suitable for adults who meet the following criteria: BMI of 30 or above, or BMI of 27 or above with a weight-related health condition such as type 2 diabetes, hypertension, or dyslipidaemia. It is not suitable for pregnant or breastfeeding women, or those with certain medical conditions including a history of thyroid cancer or pancreatitis.
What is the difference between Mounjaro and Wegovy?

Both are once-weekly injectable weight loss treatments, but they work differently. Wegovy contains semaglutide and acts on GLP-1 receptors only. Mounjaro contains tirzepatide and acts on both GLP-1 and GIP receptors. Clinical trial data suggests Mounjaro produces greater average weight loss than Wegovy, making it the more effective option for many patients.
What are the common side effects of Mounjaro?

The most commonly reported side effects are gastrointestinal in nature and include nausea, vomiting, diarrhoea, constipation, and reduced appetite. These are most likely to occur during the dose escalation phase and typically improve over time. Taking Mounjaro with food and staying well hydrated can help minimise these effects.
Are there any serious side effects I should be aware of?

Serious but rare side effects include pancreatitis, gallbladder disease, and hypoglycaemia (particularly if taken alongside other diabetes medications). Stop using Mounjaro and seek urgent medical attention if you experience severe and persistent abdominal pain, as this may indicate pancreatitis.
Can I take Mounjaro if I have type 2 diabetes?

Yes. Mounjaro is also approved for the treatment of type 2 diabetes in the UK under the brand name Mounjaro. It can improve blood sugar control alongside its weight loss benefits. However, your prescriber will need to review your full medication list, as dose adjustments to other diabetes medications may be required - this is difficult to monitor in an online setting and therefore we cannot prescribe online in this instance.
Can I drink alcohol while taking Mounjaro?

Alcohol is not contraindicated with Mounjaro, but it is advisable to moderate your intake. Alcohol can worsen gastrointestinal side effects such as nausea and may contribute to hypoglycaemia in patients also taking diabetes medications. It also adds excess calories, which may undermine your weight loss progress.
How long do I need to take Mounjaro for?

Mounjaro is intended for long-term chronic weight management. Most patients will need to continue treatment to maintain their weight loss results. Stopping Mounjaro without lifestyle changes in place may result in weight regain. Your prescriber at HEBA Online Pharmacy will review your progress regularly.
How do I get started with Mounjaro at HEBA Online Pharmacy?

Simply click the Get Started button on the Mounjaro product page and complete our short online clinical assessment. Our prescribing team will review your information and, if appropriate, issue a prescription. Your Mounjaro will then be dispensed and delivered discreetly to your door across the UK.

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